Successful Aging and Enrichment (SAGE) (NCT05128396) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Successful Aging and Enrichment (SAGE)
United States72 participantsStarted 2013-12
Plain-language summary
Progress has been made in understanding the impact of different kinds of structured intervention programs in improving cognitive processing and performance in older adults, and in determining whether there is electrophysiological evidence for neuroplasticity in individuals over the age of 65.
Who can participate
Age range65 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. Be 65 or older
✓. Have ≥ 8 years of education
✓. Be sufficiently fluent in the English language to understand instructions and perform the neuropsychological tests (as the purpose of the project is to study healthy aging)
✓. Score above levels indicating possible cognitive impairment on the Mini Mental State Exam (MMSE) (≥ 26)
✓. Have an estimated intelligence quotient (IQ) score ≥ 90 based on the American National Reading Test (AmNART)
✓. Have a score within 2 standard deviations (SD) of the age-appropriate mean on the short form of the Boston Naming Test
✓. Have a score within 2 SD of the age-appropriate mean on the Logical Memory Subtest of the Wechsler Memory Scale-Third Edition
Exclusion criteria
✕. History of Central Nervous System (CNS) diseases or major psychiatric disorders based on Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria
✕. Score of greater than 10 on the Geriatric Depression Scale
✕. Corrected visual acuity worse than 20-50 as tested by a Snellen wall chart
✕. Severe hearing disability that would interfere with their ability to participate in the experiments (e.g., to hear instructions and participate in cognitive testing)
✕
What they're measuring
1
Cambridge Neuropsychological Test Automated Battery (CANTAB), a computerized assessment of cognitive functions
Timeframe: Baseline
2
Cambridge Neuropsychological Test Automated Battery (CANTAB), a computerized assessment of cognitive functions
Timeframe: End of Study - 5 weeks post-baseline
3
Trail Making Test A
Timeframe: Baseline
4
Trail Making Test A
Timeframe: End of Study - 5 weeks post-baseline
5
Trail Making Test B
Timeframe: Baseline
6
Trail Making Test B
Timeframe: End of Study - 5 weeks post-baseline
7
Digit Symbol Coding, Weschler Adult Intelligence Scale (WAIS-IV)
Timeframe: Baseline
8
Digit Symbol Coding, Weschler Adult Intelligence Scale (WAIS-IV)
. Medical conditions (e.g., heart or pulmonary disease) that would prevent them from participating in the physical exercise training program
✕. Evidence of substantial functional decline based on interview questions and completion of a questionnaire based on the Clinical Dementia Rating Scale by an informant who knows the subject well