Successful Aging and Enrichment (SAGE) (NCT05128396) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Successful Aging and Enrichment (SAGE)
United States72 participantsStarted 2013-12
Plain-language summary
Progress has been made in understanding the impact of different kinds of structured intervention programs in improving cognitive processing and performance in older adults, and in determining whether there is electrophysiological evidence for neuroplasticity in individuals over the age of 65.
Who can participate
Age range
65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Be 65 or older
. Have ≥ 8 years of education
. Be sufficiently fluent in the English language to understand instructions and perform the neuropsychological tests (as the purpose of the project is to study healthy aging)
. Score above levels indicating possible cognitive impairment on the Mini Mental State Exam (MMSE) (≥ 26)
. Have an estimated intelligence quotient (IQ) score ≥ 90 based on the American National Reading Test (AmNART)
. Have a score within 2 standard deviations (SD) of the age-appropriate mean on the short form of the Boston Naming Test
. Have a score within 2 SD of the age-appropriate mean on the Logical Memory Subtest of the Wechsler Memory Scale-Third Edition
Exclusion criteria
. History of Central Nervous System (CNS) diseases or major psychiatric disorders based on Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria
. Score of greater than 10 on the Geriatric Depression Scale
. Corrected visual acuity worse than 20-50 as tested by a Snellen wall chart
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Cambridge Neuropsychological Test Automated Battery (CANTAB), a computerized assessment of cognitive functions
Timeframe: Baseline
2
Cambridge Neuropsychological Test Automated Battery (CANTAB), a computerized assessment of cognitive functions
Timeframe: End of Study - 5 weeks post-baseline
3
Trail Making Test A
Timeframe: Baseline
4
Trail Making Test A
Timeframe: End of Study - 5 weeks post-baseline
5
Trail Making Test B
Timeframe: Baseline
6
Trail Making Test B
Timeframe: End of Study - 5 weeks post-baseline
7
Digit Symbol Coding, Weschler Adult Intelligence Scale (WAIS-IV)
. Severe hearing disability that would interfere with their ability to participate in the experiments (e.g., to hear instructions and participate in cognitive testing)
. Medical conditions (e.g., heart or pulmonary disease) that would prevent them from participating in the physical exercise training program
. Evidence of substantial functional decline based on interview questions and completion of a questionnaire based on the Clinical Dementia Rating Scale by an informant who knows the subject well
Digit Symbol Coding, Weschler Adult Intelligence Scale (WAIS-IV)