Proton Pencil Beam Scanning GRID for Treatment of Bulky Tumors

Inclusion Criteria: * Age \> 18 * Histologically or cytologically confirmed invasive cancer * Bulky tumor \> 7 cm, determined clinically and/or radiographically, at the time of evaluation prior to enrollment * Treated indicated for palliative intent * Eastern Cooperative Oncology Group (ECOG) performance status \< 2 * Anticipated treatment deemed safe on pre-review by PI * For patients with prior Radiation Therapy (RT): Dicoms must be available for dose fusion if overlap anticipated with GRID * Willing and able to provide informed consent * Discussion with medical oncology or surgical specialty Exclusion Criteria: * Age \< 18 * ECOG performance status 3-4 * Planned for definitive, curative management * For patients with prior RT that overlaps with Pro-GRID: Dicoms not available Pregnant women * Tumor encasing critical structure, as defined by the treating MD.