Treatment of Major Depression by rTMS on Dorsolateral Prefrontal Cortex: Study of Underlying Mechanisms

Inclusion Criteria: * Diagnosis of MDD (Diagnostic and Statistical Manual of Mental Disorders V \[DSM-V\] and (Mini International Neuropsychiatric Interview \[MINI\] criteria, QIDS-C16≥18) * Right-handed * No response at a first antidepressant * Under AD ≥ 6 weeks * No contraindications for rTMS and MRI * Absence of addictive comorbidities * Absence of severe progressive neurologic and/or somatic pathologies (specially tumors, neurodegenerative diseases) * Inpatients or outpatients of Adult Psychiatric Department * Signed informed consent form * Subjects affiliated to or beneficiary from a French social security regime Exclusion Criteria: * Subjects under 35 years old or over 65 years old * Treated with over 4 AD for the current episode * ECT or rTMS for current episode * BZD or antiepileptic (except pregabalin up to 75 mg / d, zopiclone ≤7.5 mg / d) * Left-handed * Subject under measure of protection or guardianship of justice * Presence of psychiatric comorbidities * Subject beneficiary from a legal protection regime * Subject unlikely to cooperate or low cooperation stated by investigator * Subject not covered by social security * Pregnant woman * Subject being in the exclusion period of another study or provided for by the "National Volunteer File