Neurological complications after acute carbon monoxide (CO) poisoning can range from transient headache or dizziness to cognitive dysfunction, seizure, permanent anoxic brain damages or death. A recent study reported that a lack of standard pupillary light reflex (sPLR), assessed using a pen light, was a predictor of 30-day neurological sequelae in patients with CO poisoning. Given that the basic sPLR has a poor inter-rater reliability, more objective and quantitative methods are required in the assessment of PLR. An automated pupillometer has been used in the intensive care unit to quantitatively assess the PLR. Therefore, we hypothesized that quantitative assessment of PLR might be associated with neurocognitive sequelae after acute CO poisoning. The purpose of this study was to assess the value of quantitative pupillary reactivity (NPi and qPLR) in comparison to that of sPLR in predicting neurocognitive outcome at 1 month after acute CO poisoning.
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The prediction of neurological pupil index (NPi) for poor neurocognitive outcome
Timeframe: Within 3 days after acute CO poisoning
The prediction of quantitative pupillary light reflex (qPLR) for poor neurocognitive outcome
Timeframe: Within 3 days after acute CO poisoning
Comparison of predictive value for poor neurocognitive outcome between NPi and standard pupillary light reflex (sPLR)
Timeframe: Within 3 days after acute CO poisoning
Comparison of predictive value for poor neurocognitive outcome between qPLR and sPLR
Timeframe: Within 3 days after acute CO poisoning