Zinc Supplementation and Behçet's Syndrome (NCT05098678) | Clinical Trial Compass
CompletedNot Applicable
Zinc Supplementation and Behçet's Syndrome
Iran50 participantsStarted 2020-08-22
Plain-language summary
To study the effects of zinc gluconate supplementation on patients with Behçet's syndrome, 50 patients will be randomly allocated to two groups: placebo group or zinc group (one tablet of 30 mg/day elemental zinc) for 12 weeks. All participants will be asked not to alter their diet, medication, and physical activity during the study. At the first and the end of the intervention, genes and proteins expression, the serum level of inflammatory factors, quality of life, disease activity, anthropometric measures, physical activity and serum level of zinc will be assessed and compared between groups.
Who can participate
Age range
20 Years – 50 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age range 20 to 50 years (premenopausal woman)
* Diagnosis of Behcet's disease by a rheumatologist according to IBCD (The International Criteria for Behcet's Disease)
* Patients who want to participate in the study
Exclusion Criteria:
* Pregnancy and lactation
* History of diabetes and other chronic diseases
* Smoking and alcohol consumption over the past year
* History of other autoimmune diseases
* Consumption of nutritional and antioxidant supplements over two months prior to the study
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial focused on zinc supplementation specifically measuring inflammatory markers like TNF-alpha, interleukin-1 beta, and Toll-like Receptor gene expression in Behçet's patients — has the data been published yet, and if so, did zinc actually show meaningful changes in those markers?
2Since this was a completed trial labeled 'Phase NA,' which often means it was more of a mechanistic or exploratory study rather than a definitive treatment trial, does that mean we don't yet know if zinc supplementation is clinically effective for managing my Behçet's symptoms?
3The trial measured zinc serum levels alongside immune system markers — could my current zinc levels be tested to see if I'm deficient, and would that affect whether zinc supplementation might even be relevant for me?
4Given that the trial looked at the NLRP3 and Caspase-1 pathway, which is involved in inflammation in Behçet's, how does zinc supplementation compare to the standard treatments I might already be a candidate for, like colchicine or immunosuppressants?
5Are there any safety concerns about zinc supplementation at the doses used in this kind of research that I should be aware of before considering it as something to add to my current treatment plan?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.