Growth Hormone Pretreatment in Poseidon Type IV Undergoing ICSI Using Minimal Induction Protocol: A Randomized Controlled Trial

Inclusion Criteria: * -Age group between 35 to 42 years old * AFC \<5 * AMH \<1.2 ng/ml * first IVF trial Exclusion Criteria: * \- Serious and unstable disease, such as cerebrovascular, liver, and kidney disease "will be unfit for pregnancy". * History of malignant or border line tumors "will be unfit for pregnancy". * Endocrine or metabolic disorder "affecting quality of oocyte so affecting results". * Either one of the couple with chromosomal abnormalities "affecting quality of oocyte so affecting results". * Male partner with severe oligoasthenozoospermia or with teratozoospermia"affecting quality of embryo to be transfered so affecting results". * Any contraindications to growth hormone, pregnancy (to be ruled out and documented before GH treatment). * female patients with causes of infertility other than poor ovarian reserve * females suffering from congenital or acquired uterine anomalies "will affect results of implantation and pregnancy rates " * females with focal uterine lesions anomalies "will affect results of implantation and pregnancy rates " * BMI \>30 kg/m2 "affecting quality of oocyte so affecting results".