Multi-cohort exploratory prospective study. Participation in the ALCINA 4 study does not change the standard management of the patient, including the treatments administered. A sampling schedule will be set up for each cohort. Depending on the clinical context studied and the biomarkers studied and/or sought, the timing of blood samples will vary between cohorts. There may be up to 4 samples (or more) taken per patient for up to 18, 24 or 36 months. If a specific tumor sample is required, it will be collected only once during the study.
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Detection rate of circulating biomarkers in cohort 1
Timeframe: Baseline
Detection rate of circulating biomarkers in cohort 2
Timeframe: Baseline
Detection rate of circulating biomarkers in cohort 2
Timeframe: Before treatment
Detection rate of circulating biomarkers in cohort 2
Timeframe: At 3 weeks of treatment
Detection rate of circulating biomarkers in cohort 2
Timeframe: At 9 weeks of treatment
Detection rate of circulating biomarkers in cohort 2
Timeframe: At disease progression
Detection rate of circulating biomarkers in cohort 1
Timeframe: Before surgery
Detection rate of circulating biomarkers in cohort 1
Timeframe: After surgery (from 3 to 5 weeks)
Detection rate of circulating biomarkers in cohort 1
Timeframe: After surgery (from 2 to 3 months)
Detection rate of circulating biomarkers in cohort 3
Timeframe: Baseline
Detection rate of circulating biomarkers in cohort 3
Timeframe: At the end of cycle 1 (each cycle is 21 days)
Detection rate of circulating biomarkers in cohort 3
Timeframe: After surgery (from 2 to 3 months)
Detection rate of circulating biomarkers in cohort 3
Timeframe: At disease progression
Detection rate of circulating biomarkers in cohort 4
Timeframe: At pre-surgery or before starting treatment
Detection rate of circulating biomarkers in cohort 4
Timeframe: At 6 weeks after surgery or after start of treatment