Study of ARO-C3 in Adult Healthy Volunteers and Patients With Complement Mediated Renal Disease

Inclusion Criteria (All Participants): * Willing to provide written informed consent and to comply with study requirements * Female participants must be non-pregnant/non-lactating * Healthy volunteers must be willing to be vaccinated with a meningococcal and pneumococcal vaccine. C3G and IgAN participants must have been vaccinated or willing to undergo vaccination * All participants must be willing to be vaccinated or have a history of vaccination for Haemophilus influenzae * Body Mass Index (BMI) between 18.0 and 35.0 kg/m2 * 12-lead electrocardiogram (ECG) at Screening with no abnormalities that may compromise participant's safety at discretion of investigator * Participants of childbearing potential must use highly effective contraception during the study and for at least 12 weeks following the end of the study or last dose of study drug, whichever is later. Males must not donate sperm during the study and for at least 12 weeks following the end of the study or last dose of study drug, whichever is later. * No abnormal finding of clinical relevance at the Screening evaluation that, in the opinion of the investigator, could adversely impact participant safety or study results Inclusion Criteria (C3G and IgAN Participants): * Diagnosis of C3G or IgAN * Clinical evidence of ongoing disease based on significant proteinuria * Estimated glomerular filtration rate ≥30 mL/Min/1.73 m2 at Screening and currently not on dialysis * Must be on a maximally recommended or tolerated do…