Investigator Initiated Study to Assess the Efficacy of OC-01 (Varenicline) Nasal Spray on Signs and Symptoms of Dry Eye Disease Following Laser-assisted in Situ Keratomileusis (LASIK)

Inclusion Criteria: * Be willing and able to sign the informed consent form (ICF) * Be at least 18 years of age at the screening visit * Be undergoing LASIK treatment in one or both eyes * Be myopic between -1.00D to -7.00D MRSE (manifest refraction spherical equivalent) in study eye (right eye) with ≤2D between eyes or subjects undergoing monovision treatment with study eye (distance eye) meeting the diopter requirement of myopia * Be literate and able to complete questionnaires independently * Be able and willing to use the study drug and participate in all study assessments and visits * Have sufficient hand strength, in the opinion of the Investigator, to be able to independently administer the study drug * Have provided verbal and written informed consent * If a female is of childbearing potential, they must: use an acceptable means of birth control (acceptable methods of contraception include: hormonal - oral, implantable, injectable, or transdermal contraceptives, mechanical - spermicide in conjunction with a barrier such as a diaphragm or condom, IUD, or surgical sterilization of partner), and have a negative urine pregnancy test on baseline Exclusion Criteria: Subjects must not: * Have a break in the integrity of the corneal epithelium such as a persistent corneal epithelial defect, or corneal ulcer. * Have presence of corneal pathology that may interfere with LASIK outcomes * Active infectious, ocular or systemic disease * Have a history of ocular inflammation or…