Amiloride in Nephrotic Syndrome (NCT05079789) | Clinical Trial Compass
TerminatedPhase 3
Amiloride in Nephrotic Syndrome
Stopped: Low recruiting rate and decision to evaluate as pilot study
Germany20 participantsStarted 2020-06-08
Plain-language summary
The AMILOR study compares treatment of edema in nephrotic syndrome with Amiloride vs. Furosemide.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Acute nephrotic syndrome with proteinuria \> 3 g/day and formation of edema.
. Age ≥ 18 years at the time of signing the informed consent.
. Understand and voluntarily sign an informed consent document prior to any study related assessments/procedures.
. Ability to adhere to the study visit schedule and other protocol requirements.
. Use of adequate thrombosis prophylaxis due to the increased risk of thrombosis in nephrotic syndrome and the expected fluctuations in volume balance during study participation.
. Subject (male or female) is willing to use highly effective methods of contraception according to the "Clinical trial fertility group" recommendations.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial was terminated before completing — can you help me understand why it was stopped early, and what that means for the reliability of any data that was collected about amiloride for nephrotic syndrome?
2Since the trial was measuring changes in overhydration and fluid balance after just 8 days, does that short timeframe tell us anything useful about whether amiloride could help manage my long-term fluid retention and edema?
3Amiloride is already an approved diuretic used in other conditions — given that this trial didn't finish, is there enough existing evidence for you to consider it as part of my treatment plan, or would a more established approach be a better first step for me?
4Because this was a Phase 3 trial focused on sodium retention and fluid overload in nephrotic syndrome, how does amiloride compare to the diuretics I might already be prescribed, and are there any known risks specific to using it with kidney-related conditions like mine?
5Since the trial was terminated, are there other ongoing or completed studies on managing edema and sodium retention in nephrotic syndrome that you think would be more relevant for me to look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.