Comparison Between Two Durations of Antibiotherapy for Non-surgically-treated Diabetic Foot Osteomyelitis (CHRONOS-2)

Inclusion Criteria: * Patient aged ≥ 18 years * Informed, written consent obtained from patient * Patient having the rights to Frenc social insurrance * For women of childbearing potential : any effective contraceptive is required * Type 1 or 2 diabetic patients * Diabetic patients treated non-surgically for an osteomyelitis of the forefoot affecting only one osteoarticular part/radial supported by adequate diagnostic imaging and bone biopsy performed through uninfected tissue. * Two peripheral pulses or transcutaneous oxygen tension measurement (TcPO2 \> 30mmHg) or ankle brachial index (ABI \> 0.9) * Patient without antibiotherapy during 2 weeks before D1. * Glycated hemoglobin (HbA1C) \< 12% ( measured maximum 2 months before D1) * Use of offloading boot for diabetic foot is feasible Exclusion Criteria: * Bone fragmentation, articular destruction requiring bone resection or amputation. * Gangrene * More than one osteoarticular part/radial affected * Contraindication for the use of offloading boot * Contraindication for bone biopsy * Contraindication for the full course of antibiotics (allergy or based on RCP) * Other drug-drug interaction that contraindicated the full course of antibiotics * Charcot foot * Patient undergoing radiotherapy of chimiotherapy for malignant neoplasms * Hepatic insufficiency (ASAT and/or ALAT \> 3 times the normal level) * Any disease or behaviour making impossible to follow the protocol or difficult to interpret the results * Any disease or co…