This study is designed to investigate how musical patterns (e.g., patterned sensory enhancement, PSE) and non-invasive brain stimulation (e.g., transcranial direct current stimulation, tDCS) are effective to improve functional upper extremity performances in patients with corticobasal syndrome (CBS). 20 individuals with CBS will be randomly assigned to either PSE group (n= 10) or PSE+tDCS (n=10) group. Both interventions are 30 minutes long, twice a week for three weeks (a total of 6 sessions). Participants' self-reported and measurable outcomes including upper extremity function, kinematic quantities, quality of life, mood, cognitive level, and brain activity (e.g. electroencephalography, EEG) will be assessed in the baseline, pre- and post- each session, and follow-up phase. This study seeks to assess the possibility that music-based intervention and non-invasive brain stimulation may improve outcomes in CBS patients for patients' non-invasive but cost-effective rehabilitation settings in the future.
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Change in functional upper extremity performance score as assessed by the WMFT
Timeframe: Baseline (Day1), Day 24, and Day 52
Change in TOLA score (limb)
Timeframe: Baseline (Day1), Day 24, and Day 52
Change in TOLA score (oral)
Timeframe: Baseline (Day1), Day 24, and Day 52
Change in TOLA score (pictures)
Timeframe: Baseline (Day1), Day 24, and Day 52
Change in TOLA score (command)
Timeframe: Baseline (Day1), Day 24, and Day 52
Change in TOLA score (imitation)
Timeframe: Baseline (Day1), Day 24, and Day 52
Changes in number of pegs placed in 30 seconds
Timeframe: Baseline (Day 1), Day 8, Day 10, Day 15, Day 17, Day 22, Day 24, and Day 52
Change in number of blocks transferred from one compartment to the other compartment in 60 seconds
Timeframe: Baseline (Day 1), Day 8, Day 10, Day 15, Day 17, Day 22, Day 24, and Day 52