Effects of Novel Estrogens on Glucose and Lipids in Postmenopausal Prediabetic Women Veterans

Inclusion Criteria: Postmenopausal women veterans within 5 years of menopause. Menopause is defined as: * women with intact uterus and last menstrual period \>1 year ago but \<5 years ago * Age 50-60 years * BMI 27-34.9kg/m2 (Overweight and low risk Class 1 Obesity) * Symptomatic (moderate to severe vasomotor symptoms) * Fasting glucose 100-150mg/dl or/or HbA1c \>5.7%- and \<7% (two abnormal test can be fasting glucose or HbA1c or combination of the two in the past 6 months). * Triglycerides \< 200 mg/dl * GFR \>60mL/min * Normal mammogram within the past 12 months Exclusion Criteria: * Amenorrhea from other causes (Hyperandrogenemia and anovulation) * Recent weight change (\>10 lbs in the last 3 months), intended or unintended * Vulnerable populations (employees, students, individuals with impaired decision making capacity, pregnant women, prisoners, terminally ill, and children) * Change in lipid lowering agent in the last 3 months * Use of glucose lowering agents in the last 3 months * Concurrent conditions including HIV, uncontrolled hyperthyroidism, uncontrolled hypothyroidism or less than 3 months since addition or change in thyroid hormone modulating medications, current use of drugs known to promote significant weight changes, menopause hormone therapy use within 3 months * Contraindications to estrogens (history of thromboembolic disorder, coronary artery or cerebrovascular disease, clotting disorders (Antiphospholipid antibody syndrome, protein C deficiency, pr…