Acute Timed Exercise and 24h Metabolism

Inclusion Criteria: * Signed informed consent * Healthy (determined by dependent physician) * Man or post-menopausal woman * Age between 50 - 75 years * BMI ≥ 25 kg/m2 * Pre-diabetes based on meeting at least one of the following criteria: impaired glucose tolerance defined as plasma glucose values ≥ 7.8 mmol/l and ≤ 11.1 mmol/l 120 minutes after glucose drink consumption during oral glucose tolerance test in screening, impaired fasting glucose defined as fasting plasma glucose ≥ 6.1 mmol/l and ≤ 6.9 mmol/l, insulin resistance defined as a glucose clearance rate ≤ 360 mL/kg/min as determined using OGIS120, HbA1c of 5.7-6.4% * Regular sleeping habits (7 - 9h of daily sleep) * Stable diet and weight: No weight gain or loss \> 3kg in the last three months Exclusion Criteria: * Not meeting all inclusion criteria * Fasting plasma glucose * ≥ 7.0 mmol/L * Hemoglobin \< 7.8 mmol/L * Previously diagnosed with type 2 diabetes * Uncontrolled hypertension * In case of an abnormal electrocardiogram at rest: this will be discussed with the responsible medical doctor * Subjects who do not want to be informed about unexpected medical findings during the screening /study, or do not wish that their physician is informed * Any contra-indication to the Equivital telemetric pill * Hypomotility disorders of the gastro-intestinal tract * Extreme early bird or extreme night person (score ≤30 or ≥70 on morning-eveningness questionnaire self assessment) * Heavily varying sleep-wake rhythm * Night …