OMT as an Adjunctive Treatment in MDD

Inclusion Criteria: * patients 18-65, patients with diagnosis of MDD, PHQ-9 score \> 10 at screening and baseline Exclusion Criteria: * history of mania, hypomania, or psychosis as defined in DSM V * current substance abuse, including abuse within the previous 6 months * patients with a cognitive disorder or dementia * patients with other axis I diagnosis (anxiety disorders, dissociative disorders, etc.) that was primary in the past 6 months * receiving other forms of manual therapy during study * authors belief that there was significant suicidal risk * changes in medication or psychotherapy within 6 weeks of starting study or during study period * history of migraines * presence of any other significant organic disease (infectious, cardiac, pulmonary, gastrointestinal, renal, etc.) * other absolute contraindications to OMT (malignancy, infection, myelopathy, severe osteoporosis, increased ICP, intracranial bleeding, fractures, etc.)