CompletedNot Applicable

Hemostatic Profiles in Pediatric CKD

United States8 participantsStarted 2021-11-15

Plain-language summary

This cross-sectional pilot study will examine the blood clotting patterns in children with chronic kidney disease stages 3, 4, and 5. A total of 30 participants will be enrolled with 10 participants for each stage of chronic kidney disease. Blood specimens will be collected from each participant during a routine clinic visit, and will then be processed to evaluate blood clotting characteristics according to thrombelastography and more conventional clotting tests.

Who can participate

Age range6 Months – 17 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Pediatric patients ages 6 months - 17 years * Currently followed in the CKD clinic at Children's Healthcare of Atlanta (CHOA) * Diagnosed with Stage 3, Stage 4 or Stage 5 CKD * Must have routine venous laboratory tests planned as a component of their clinic encounter. Exclusion Criteria: * Participants \<13.6kg (to allow for safe blood sample volumes). * History of venous thromboembolism, post solid organ transplant, co-diagnosis of inflammatory disease, and nephritis. * Personal or family history of inherited thrombophilia conditions * Hospital admission within the last 30 days. * Transfusion (PRBC, FFP, Platelets, or Cryoprecipitate) within the last 30 days. * Those on the following medications: steroids and anti-coagulants.

What they're measuring

Degree of statistically-significant correlation between conventional clotting tests and thrombelastography when determining the degree of hypercoagulability for pediatric patients diagnosed with chronic kidney disease stages 3, 4, and 5

Timeframe: Day 1

Trial details

NCT IDNCT05064267

SponsorChildren's Healthcare of Atlanta

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2022-05-10