Dose-Finding Study of Intranasal Insulin in Healthy Participants Insulin in Healthy Participants

Inclusion Criteria: * Good health based on medical history, physical exam, and routine laboratory testing. * Female participants must have negative urine pregnancy test or be surgically sterilized or postmenopausal. Criteria for menopause are surgical menopause (hysterectomy, oophorectomy) or age \> 45 years with the absence of menses for greater than 12 months. Tubal ligation with menses within the past 12 months is not considered to be surgical sterilization. * Body mass index (BMI) between 18 kilogram / square meter (kg/m2) and 35 kg/m2. * Willing and able to stay at the clinical research facility as required by the protocol * Willing and able to comply with the investigational nature of the study and able to communicate well with investigators * Ability to comprehend and willing to provide written informed consent in accordance with institutional and regulatory guidelines Exclusion Criteria: * Known allergy to insulin. * Preexisting diabetes. * Current or previous use of diabetes medication or insulin. * Any nasal disease or congestion that may interfere with intranasal drug absorption. * Baseline hypoglycemia (blood glucose ≤ 65 mg/dL) or hyperglycemia (blood glucose \> 200 mg/dL) as evident from the screening labs. * Active serious disease, such as liver disease, kidney disease, uncontrolled hypertension, clinically significant hypokalemia, and significant or unstable medical illness * Blood donation in excess of 500 milliliter (mL) within 60 days prior to the first …