Post-Revascularization Optimization and PHysiological Evaluation of intermediaTe Lesions

Inclusion Criteria: * requiring coronary angiography to assess coronary artery disease; * having at least one angiographically intermediate coronary stenosis (eg. 40%-80%) on any vessel requiring invasive functional assessment using FFR (and/or any other surrogate index) * being able and legally entitled to give informed consent Exclusion Criteria: * history of severe poorly uncontrolled pulmonary disease * hemodynamic instability during the diagnostic or therapeutic procedures; * known adenosine intolerance * need of mechanical circulatory or ventilatory support; * stage IV chronic kidney disease. * life expectancy \<1 year * patients gaining indication to surgical revascularization; * major procedural complications during percutaneous revascularization (cardiac arrest needing cardiopulmonary resuscitation, major bleeding , large iatrogenic coronary dissection, coronary embolization in a main vessel, suspected stroke) making post-PCI functional evaluation unsafe or impossible.