The Role of the Kidneys and Liver in the Elimination of Glucagon

Inclusion Criteria: The CKD group * Men/women between 18 and 75 years of age * CKD stage 4 or 5 * Normal liver function (alanine aminotransferase (ALAT), aspartate aminotransferase (ASAT), albumin and coagulation factor II, VII and X (INR) within normal range, * Informed consent The cirrhosis group * Men/women between 18 and 75 years of age * Verified diagnosis of cirrhosis - Child-Pugh Score of 5-12 * Normal kidney function (estimated glomerular filtration rate (eGFR) above 60 ml/min/1.73m2 and absence of proteinuria) * Informed consent The control group * Men/women between 18 and 75 years of age * Normal kidney function (estimated glomerular filtration rate (eGFR) above 60 ml/min/1.73m2 and absence of proteinuria)(plasma creatinine ≤105 micromol/L (µM) for men and ≤90 µM for women) * Normal liver function (alanine aminotransferase (ALAT), aspartate aminotransferase (ASAT), albumin and coagulation factor II, VII and X (INR) within normal range * Informed consent Exclusion Criteria: All groups * Diagnosis of diabetes and/or HbA1c ≥43 mmol/mol and/or fasting plasma glucose ≥6 mmol/l. * Previous kidney transplantation with remaining kidney graft * Present treatment with oral glucocorticoids * Polycystic kidney disease * Pregnancy or breastfeeding * Inflammatory bowel disease * Surgical procedure within the last 3 months * Haemoglobin \< 6 mmol/l (women) or \< 7 mmol/l (men) * First-degree relatives with diabetes * Any condition that the investigators feel would interfe…