WithdrawnNot Applicable

Comparison of the Concentration of Estrogen and Testosterone Ratio in Male Patients With Cirrhosis and Hypotension

Stopped: Study will be changed from prospective to retrospective

0Started 2021-08-22

Plain-language summary

Cirrhosis is an end stage in liver disease leading to replacement of normal liver tissue with regenerative nodules surrounded by fibrous bands in response to chronic liver injury. It is the eighth leading cause of death in the United States and the thirteenth leading cause of death globally. Patients with cirrhosis have decreased spontaneous vascular resistance leading to hypotension. The mechanism of hypotension in cirrhosis is thought to be a complex result of the presence of increased level of circulating vasodilators such a nitric oxide coupled with reduced resistance to vasoconstrictors and increased sensitivity to vasodilators.

Who can participate

Age range18 Years

SexMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Male cirrhotic patients \>18 years of age * Patient must attend the outpatient clinic of the Liver Institute at Methodist Dallas Medical Center * willing to provide informed consent to participate in the study Exclusion Criteria: * Patients with a history of cirrhosis \<18 years of age * Cirrhosis patients with active infection * Cirrhosis patients with active gastrointestinal bleeding * Cirrhosis patients on hormone replacement therapy testosterone * Cirrhosis patients on any antihypertensive medications

What they're measuring

Serum estrogen (E1 and E2) levels

Timeframe: July to September 2021

Serum testosterone levels

Timeframe: July to September 2021

Trial details

NCT IDNCT05051293

SponsorMethodist Health System

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2022-08-17

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