Comprehensive Evaluation of Tumor Oxygenation, Metabolism and Blood Supply of High Grade Glioma and Cervical Cancers Using Dynamic FAZA PET and Multiparametric MR

Inclusion Criteria: Glioma Cohort * Adult (\> 18 years old) patients with newly diagnosed or recurrent high grade glioma with newly confirmed pathology (within 1 month) * Able to provide informed consent * No contraindications to MRI with gadolinium contrast or 18F-FAZA PET Cervical Cohort * Adult (\>18 years old) female with newly diagnosed cervical cancer * Able to provide informed consent * Receiving surgery, radiotherapy or chemotherapy * No contraindication to MRI with gadolinium contrast or 18F-FAZA PET Exclusion Criteria: Glioma Cohort * Prior nephrectomy or planned nephrectomy. * Prior brain radiation within 30 days. * Pregnant or lactating women: Pregnant women are excluded from this study because the effects of 18F-FAZA in pregnancy are not known. A urine or serum pregnancy test will be performed before enrollment after informed consent is obtained. The pregnancy test is part of SOC before imaging. * Lactation should be suspended for at least two days following the administration of 18F-FAZA to the mother, because of the unknown but potential risk for adverse events in nursing infants secondary to administration of the radionuclide to a lactating woman. * Subjects with contraindications to the use of 18F-FAZA including confirmed allergy. * Patients with a body weight of 400 pounds or more, or a BMI which precludes their entry into the bore of the PET-MRI scanner, because the findings will probably be compromised in image quality with PET-MRI. * Any additional…