Preventing Anaphylaxis With Acalabrutinib

Inclusion Criteria: * History of immunoglobulin E (IgE)-mediated food allergy to peanut or tree nut * Positive skin prick test to the trigger food (either peanut or tree nut) * Objective clinical reaction to the food allergen during baseline oral food challenge * Women of child bearing potential must agree to two forms of highly effective contraception (hormonal, device, or barrier method of birth control; abstinence) prior to study entry, for the duration of study participation, and for 7 days following completion of acalabrutinib therapy. * Ability to understand and the willingness to sign a written informed consent * Ability to clearly understand and speak English at an 8th grade reading level Exclusion Criteria: * Participants who have been on immunomodulatory therapies or oral corticosteroids within 1 month prior to enrollment * Participants with symptoms consistent with food reactions other than type 1 hypersensitivity * History of allergic reaction to acalabrutinib * History of idiopathic urticaria, dermatographism, idiopathic or unexplained anaphylaxis, or anaphylaxis (to foods or otherwise) resulting in intubation, prolonged hypotension, or neurological sequelae- History of cardiovascular disease * History of a bleeding disorder, or those currently taking blood thinners * History of stroke * History of gastrointestinal ulcer * History of cancer (other than skin cancer) * Positive HIV status or history of other immunodeficiency * Active or latent Hepatitis B or C i…