CompletedNot Applicable

Separation Versus Integrated Approach in Combining ECMO With CRRT

Thailand80 participantsStarted 2021-04-01

Plain-language summary

This study aimed to compare circuit lifespan of CRRT between Integration and Separation techniques during ECMO support.

Age range18 Years – 90 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

✓. Refractory acidosis, defined as pH \< 7.2 or serum bicarbonate (HCO₃-) \< 15 mmol/L
✓. Refractory volume overload
✓. Refractory hyperkalemia, defined as serum potassium (K⁺) \> 6.2 mEq/L or presence of electrocardiographic changes
✓. Anuria or oliguria, defined as urine output \< 0.5 mL/kg/hr for 6-12 hours
✓. Elevated BUN \>100 mg/dL or presence of uremic symptoms Increased intracranial pressure

✕. Pregnancy
✕. Heparin contraindication
✕. Chronic kidney disease with CRRT
✕. AKI with Glomerulonephritis, Interstitial nephritis, Vassculitis or Urinary tract obstruction

CRRT Circuit lifespan

Timeframe: 72 hours, extended maximum to 120 hours

NCT IDNCT05036616

SponsorChulalongkorn University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-03-10