RanDOmized stUdy Comparing Both Latest Generation Self-Expanding Valves and a Minimalist approaCH vs. Standard Of Care In transCathEter Aortic Valve Implantation

Inclusion Criteria: * Severe symptomatic aortic valve stenosis (AVA ≤1 cm² or 0.6 cm²/m²) with indication for transcatheter aortic valve implantation according to heart team consensus * Perimeter-derived native aortic valve annulus diameter measuring 21-27 mm * Heart team consensus that the patient is anatomically suitable for both device types * Suitability for transfemoral vascular access * Written informed consent Exclusion Criteria: * Life expectancy \<12 months due to comorbidities * Native aortic valve annulus \<21 mm and \>27 mm * Bicuspid aortic valve * Cardiogenic shock or hemodynamic instability * Active endocarditis * Contraindications for transfemoral access * Active peptic ulcer or upper gastro-intestinal bleeding \<2 weeks * Hypersensitivity or contraindication to aspirin, heparin or clopidogrel * Contraindication for a specific treatment strategy (minimalist approach vs. standard of care) as judged by the Heart Team * Clear patient-specific clinical or anatomic reasons to prefer one treatment strategy or valve type over the other * Active infection requiring antibiotic treatment * Age \<18 years * Participation in another interventional trial where the primary endpoint has not been reached