Mi-STITCH™ and Mi-KNOT™ Device Technologies - Improvement of Mitral Valve Repair

Inclusion Criteria: * Severe primary mitral valve regurgitation according to current guidelines with indication for mitral valve repair * With or without concomitant procedures such as: coronary artery bypass grafting (CABG), other valve repair/replacement, pacemaker implantation, exclusion of left appendage and MAZE (or PVI) procedure, aortic procedures * Euroscore II \< 8 * Left ventricle ejection fraction \> 35% * Life expectancy above 1 year after the intervention based on operator assessment * Willing to sign informed consent * Willing to undergo all medical follow-ups necessary for the clinical investigations until study termination (echocardiography, blood tests, physical investigation) Exclusion Criteria: * Age \<18 years * Active endocarditis or myocarditis * Previous cardiac surgery * Heavily calcified mitral valve annulus * Severe mitral stenosis * Female pregnant patients * Emergency procedures * Patient not able to read or understand informed consent * Patient not willing to sign informed consent