A Comparison of TULSA Procedure vs. Radical Prostatectomy in Participants With Localized Prostate Cancer

Inclusion Criteria: * Male * Age 40 to 80 years, with \>10 years life expectancy * NCCN (favorable and unfavourable) intermediate-risk prostate cancer on biopsy acquired within last 12 months * Stage ≤cT2c, N0, M0 * ISUP Grade Group 2 or 3 disease on TRUS-guided biopsy or in-bore biopsy * PSA ≤20ng/mL within last 3 months * Treatment-naïve * Planned ablation volume is \< 3 cm axial radius from urethra on mpMRI acquired within last 6 months Exclusion Criteria: * Inability to undergo MRI or general anesthesia * Suspected tumor is \> 30 mm from the prostatic urethra * Prostate calcifications \> 3 mm in maximum extent obstructing ablation of tumor * Unresolved urinary tract infection or prostatitis * History of proctitis, bladder stones, hematuria, history of acute urinary retention, severe neurogenic bladder * Artificial urinary sphincter, penile implant, or intraprostatic implant * Patients who are otherwise not deemed candidates for radical prostatectomy * Inability or unwillingness to provide informed consent * History of anal or rectal fibrosis or stenosis, or urethral stenosis, or other abnormality challenging insertion of devices