Binimetinib and Encorafenib for the Treatment of Metastatic Melanoma and Central Nervous System Metastases

Inclusion Criteria: * Able to provide written informed consent. * Age \>= 18 years at the time of informed consent * Histologically confirmed diagnosis of melanoma * Presence of BRAFV600 mutation in tumor tissue previously determined by a local assay (including immunohistochemistry \[IHC\]) at any time prior to Screening or during Screening * Cohort A: BRAF V600 mutant melanoma patients with progressive central nervous system (CNS) metastases. This includes patients with parenchymal brain metastases and/or LMD * Cohort A: Prior therapy with Food and Drug Administration (FDA)-approved BRAF inhibitors (+/- MEK inhibitors) is required * No washout period is required * Cohort A: Prior therapy with immunotherapy or other investigational agents is allowed * Washout period of 14 days since last dose * Cohort B: BRAF V600 mutant melanoma patients who are treatment naive to BRAF/MEK inhibitors with CNS metastases, including LMD. Prior treatment with immunotherapy is permitted * For patients with parenchymal brain metastases (mets) without LMD * Metastatic disease to the brain with at least 1 progressing parenchymal brain lesion \>= 0.5 cm and =\< 3 cm, defined as a magnetic resonance imaging (MRI) contrast-enhancing lesion that may be accurately measured in at least 1 dimension * For patients with LMD * Patients must have investigator assessed radiographic and/or CSF cytological evidence of LMD * Patients must have an Eastern Cooperative Oncology Group (ECOG) performance …