Stopped: Phase III PEARL studies (CQGE031C2302 and CQGE031C2303) with ligelizumab met their primary endpoint of superiority vs placebo at Week 12 for treatment of CSU, but not versus omalizumab. Decision to discontinue was not based on safety concerns.
This was a placebo controlled, phase 3 study designed to evaluate the efficacy and safety of ligelizumab in participants with chronic inducible urticaria who are inadequately controlled with H1-antihistamines
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Change From Baseline in Total Fric Score in Participants With Symptomatic Dermographism
Timeframe: Baseline, Week 12
Change From Baseline in Critical Temperature Threshold in Participants With Cold Urticaria
Timeframe: Baseline, Week 12
Change From Baseline in Itch Numerical Rating Scale in Participants With Cholinergic Urticaria
Timeframe: Baseline, Week 12