Efficacy and Safety of Emodepside in Adults Infected With Trichuris Trichiura and Hookworm

Inclusion Criteria: * Male or female adults aged between 18 and 45 years * Written and signed informed consent * Examined by a study physician before treatment * Provided two stool samples at baseline * Trichuris trichiura and hookworm EPG ≥ 48 and at least two Kato-Katz thick smears slides with more than one Trichuris trichiura and hookworm eggs Exclusion Criteria: * Pregnant or lactating and/or planning to become pregnant within three months after drug treatment * Type 1 and/or 2 diabetes * Psychiatric disorders * History of ophthalmological conditions * Presence or history of major systemic or chronic illnesses, as assessed by a medical doctor, during initial clinical assessment * Suffers from severe anaemia (Hb \< 80 g/l) * Received anthelminthic treatment within past four weeks * Attending other clinical trials during the study * Received strong CYP3A4 inducers or inhibitors as well as concomitant treatments that are relevant substrate for CYP3A4 such as clarithromycin, erythromycin and rifampicin * Received strong P-gp inhibitors as well as concomitant treatments that are relevant substrates for P-gp such as clotrimazole and ritonavir