Gamma Delta T-cell Infusion for AML at High Risk of Relapse After Allo HCT (NCT05015426) | Clinical Trial Compass
Active — Not RecruitingPhase 1
Gamma Delta T-cell Infusion for AML at High Risk of Relapse After Allo HCT
United States20 participantsStarted 2022-03-21
Plain-language summary
The purposes of the study are to determine the maximum tolerated dose (MTD) and effectiveness of Artificial Antigen Presenting Cell (AAPC)-expanded donor T-cells administered as a single infusion after an allogeneic hematopoietic cell transplant (alloHCT) to treat patients with Acute Myeloid Leukemia (AML).
Who can participate
Age range18 Years – 75 Years
SexALL
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Inclusion Criteria:
* Male or female, aged between 18 and 75 years of age undergoing allogeneic hematopoietic stem cell transplantation (alloHCT) or the treatment ELN 2017 adverse risk AML
* Have \< 5% blasts in bone marrow by morphology at the time of transplantation. Patients with pre-alloHCT or post-alloHCT flow cytometric or molecular evidence of MRD are allowed
* Karnofsky performance status (KPS) ≥ 70% during the study screening.
* Free of symptomatic congestive heart failure or uncontrolled arrhythmia
* Adequate organ function as defined per protocol
* Negative serum pregnancy test
* Note: Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control or abstinence) prior to study entry and for at least 30 days following study treatment (T-cell infusion); should a woman subject or female partner of a male subject become pregnant or suspect that she is pregnant while participating on the trial, she should inform her treating physician immediately.
* Provision of signed and dated informed consent form
* Stated willingness to comply with all study procedures and availability for the duration of the study.
* Agreement to adhere to Lifestyle Considerations throughout study duration
Exclusion Criteria:
* Current use of concomitant systemic glucocorticoid at the time of γδ T-cell infusion for any reason will not be allowed in order to avoid their immunosuppressive effects on γδ T-cell function.
* Active grade …
What they're measuring
1
Maximum Tolerated Dose
Timeframe: Up to 12 months
2
Dose Expansion: Leukemia Free Survival
Timeframe: Up to 12 months
Trial details
NCT IDNCT05015426
SponsorH. Lee Moffitt Cancer Center and Research Institute