WithdrawnPhase 3

Adenosine's Effect on STunning Resolution in Acute Myocardial Infarction

Stopped: Never started

0Started 2023-01-01

Plain-language summary

The aim of this study is to evaluate the effect of adenosine on the recovery of myocardial akinesia in ST-elevation myocardial infarction (STEMI). The study is a single-center randomized clinical trial intending to include 90 patients. The objective of the study is to investigate whether treatment with adenosine hastens recovery of myocardial akinesia and improves cardiac function at 48 hours in patients with STEMI.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Age \>18 years.
✓. Anterior STEMI.
✓. Symptom duration ≤6 hours
✓. Written informed consent obtained - Angiographic Inclusion criteria:
✓. Culprit lesion in LAD, major branch of LAD, proximal or mid LCx or proximal or mid RCA
✓. TIMI flow ≤2 in the culprit vessel
✓Echocardiographic inclusion criteria:
✓. Detectable hypo- or akinesia corresponding to ≥5% of the left ventricle corresponding to culprit lesion, per bedside visual assessment.

Exclusion criteria

✕. Previous randomization in the study
✕. Any of the following contraindications for treatment with adenosine:
✕. Known pre-existing atrioventricular block grade ≥2 or sick sinus syndrome in patients without pacemaker.
✕. Known pre-existing elevation of intracranial pressure
✕. Treatment with dipyridamole within 24 hours of randomization
✕. Systolic blood pressure \<80 mm Hg at screening

What they're measuring

The resolution of myocardial stunning at 48 hours (StunningRes48h).

Timeframe: 48 hours

Trial details

NCT IDNCT05014061

SponsorVastra Gotaland Region

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2025-06

View on ClinicalTrials.gov More Myocardial Ischemia trials