NT-3 Levels and Function in Individuals With CMT (NCT05011006) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
NT-3 Levels and Function in Individuals With CMT
United States50 participantsStarted 2027-11-13
Plain-language summary
This study will assess the serum NT-3 levels in individuals with the diagnosis of peripheral neuropathy or any type of Charcot-Marie-Tooth Neuropathy (CMT) and correlate this with function.
Who can participate
Age range7 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Males or females from 7 years of age or older
* Diagnosis of acquired peripheral neuropathy (PN) such as due to diabetes, chemo-induced, autoimmune chronic inflammatory demyelinating polyneuropathy (CIDP) established by a report of electrical studies or with a known genetic CMT diagnosis. Definitive diagnosis of PN is established with a report of electrical studies, EMG/nerve conduction studies.2
* Perform assessments to the best of their ability with reliable results as deemed by the evaluator.
* Ability to attend scheduled appointments
* Ability to provide informed consent (or assent for ages 9-18)
Exclusion Criteria:
* Current pregnancy per medical history
* Has a medical condition or extenuating circumstances that, in the opinion of the investigator, might compromise the subject's wellbeing, safety, or clinical interpretability
What they're measuring
1
Assess change in Manual Muscle Testing (MMT)
Timeframe: Compare baseline to Year 1 and Year 2 visits.
2
Assess change in 100 Meter Timed Test (100m):
Timeframe: Compare baseline to Year 1 and Year 2 visits.
3
Assess change in Timed Functional Testing:
Timeframe: Compare baseline to Year 1 and Year 2 visits.
4
Assess change in PROMIS Upper Extremity Function and Mobility Scales:
Timeframe: Compare baseline to Year 1 and Year 2 visits.
5
Assess change in Abilities Captured Through Interactive Video Evaluation (ACTIVE)
Timeframe: Compare baseline to Year 1 and Year 2 visits.
6
Assess change in CMT Pediatric Scale (CMTPedS)
Timeframe: Compare baseline to Year 1 and Year 2 visits.
7
Assess change in Timed Up and Go
Timeframe: Compare baseline to Year 1 and Year 2 visits.