Not Yet RecruitingNot Applicable

NT-3 Levels and Function in Individuals With CMT

United States50 participantsStarted 2027-11-13

Plain-language summary

This study will assess the serum NT-3 levels in individuals with the diagnosis of peripheral neuropathy or any type of Charcot-Marie-Tooth Neuropathy (CMT) and correlate this with function.

Who can participate

Age range

7 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Males or females from 7 years of age or older * Diagnosis of acquired peripheral neuropathy (PN) such as due to diabetes, chemo-induced, autoimmune chronic inflammatory demyelinating polyneuropathy (CIDP) established by a report of electrical studies or with a known genetic CMT diagnosis. Definitive diagnosis of PN is established with a report of electrical studies, EMG/nerve conduction studies.2 * Perform assessments to the best of their ability with reliable results as deemed by the evaluator. * Ability to attend scheduled appointments * Ability to provide informed consent (or assent for ages 9-18) Exclusion Criteria: * Current pregnancy per medical history * Has a medical condition or extenuating circumstances that, in the opinion of the investigator, might compromise the subject's wellbeing, safety, or clinical interpretability

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Assess change in Manual Muscle Testing (MMT)

Timeframe: Compare baseline to Year 1 and Year 2 visits.

Assess change in 100 Meter Timed Test (100m):

Timeframe: Compare baseline to Year 1 and Year 2 visits.

Assess change in Timed Functional Testing:

Timeframe: Compare baseline to Year 1 and Year 2 visits.

Assess change in PROMIS Upper Extremity Function and Mobility Scales:

Timeframe: Compare baseline to Year 1 and Year 2 visits.

Assess change in Abilities Captured Through Interactive Video Evaluation (ACTIVE)

Timeframe: Compare baseline to Year 1 and Year 2 visits.

Assess change in CMT Pediatric Scale (CMTPedS)

Timeframe: Compare baseline to Year 1 and Year 2 visits.

Assess change in Timed Up and Go

Timeframe: Compare baseline to Year 1 and Year 2 visits.

Trial details

NCT IDNCT05011006

SponsorZarife Sahenk

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2030-06

Contact for this trial

Dawn Scott, RN

614722-2715 Dawn.Scott@nationwidechildrens.org

View on ClinicalTrials.gov More Charcot-Marie-Tooth Disease trials

Who can participate

Age range

7 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Assess change in Manual Muscle Testing (MMT)

Timeframe: Compare baseline to Year 1 and Year 2 visits.

Assess change in 100 Meter Timed Test (100m):

Timeframe: Compare baseline to Year 1 and Year 2 visits.

Assess change in Timed Functional Testing:

Timeframe: Compare baseline to Year 1 and Year 2 visits.

Assess change in PROMIS Upper Extremity Function and Mobility Scales:

Timeframe: Compare baseline to Year 1 and Year 2 visits.

Assess change in Abilities Captured Through Interactive Video Evaluation (ACTIVE)

Timeframe: Compare baseline to Year 1 and Year 2 visits.

Assess change in CMT Pediatric Scale (CMTPedS)

Timeframe: Compare baseline to Year 1 and Year 2 visits.

Assess change in Timed Up and Go

Timeframe: Compare baseline to Year 1 and Year 2 visits.