Retinopathy of prematurity (ROP) is a disorder of development of the neural retina and its vasculature that can impact vision in vulnerable preterm neonates for a lifetime. This study tests high-speed optical coherence tomography (OCT) technology compared to conventional color photographs at the bedside of very preterm infants in the intensive care nursery, to characterize previously unseen abnormalities that can predict a need for referral for ROP treatment, or poor visual or neurological development later in life, up to pre-school age. Our long-term goal is to help improve preterm infant health and vision via objective bedside imaging and analysis that characterizes early critical indicators of ROP, and poor visual function and neurological development, which will rapidly translate to better early intervention and improved future care.
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Optotype Visual acuity scores (Cohort 1 only)
Timeframe: 5-year study visit
Visual function scores (Cohort 1 only)
Timeframe: 4.75-year study visit
Neurodevelopmental scores at 2-year study visit (Cohort 1 only)
Timeframe: 2-year study visit
Retinal thickness at the fovea and surrounding optic nerve as measured by OCT reading (Cohort 1-3)
Timeframe: Up to 42 weeks post-menstrual age
Microanatomy as measured by OCT reading
Timeframe: Up to 42 weeks post-menstrual age
Microanatomy as measured by retinal photo reading (Cohort 3 only)
Timeframe: Up 42 weeks post-menstrual age
Microanatomy as measured by clinical exam (Cohort 1-3)
Timeframe: Up to 42 weeks post-menstrual age
Measurement of stress of imaging (Cohort 3 only)
Timeframe: Up to 42 weeks post-menstrual age
Assessment of ease of imaging (Cohort 3 only)
Timeframe: Up to 42 weeks post-menstrual age
ROP vascular severity score (Cohort 3 only)
Timeframe: Up to 42 weeks post-menstrual age