Phase IB/II of CPX-351 for Relapse Prevention in AML

Inclusion Criteria: * Newly diagnosed patients \> 18 years of age * Patients must be in CR or CRh (complete remission with partial count recovery). * Must have received ANY induction treatment with standard consolidation or hypomethylating agent (HMA) + venetoclax, for up to 6 cycles or no more than 12 cycles of treatment. * Must be able to start therapy within 3 months of last documented CR * De novo or secondary AML/treatment related AML (non-M3) including AML with myelodysplasia-related changes (MRC), histologically confirmed * Patients must be ineligible for allogeneic BMT (for any reason including poor performance status, patient's preference, favorable AML not a candidate for transplant, or comorbidities and age precluding from transplant etc) * Cardiac ejection fraction ≥ 50% by transthoracic echocardiography or MUGA scan * Adequate hepatic and renal function defined as: * Serum aspartate transaminase (AST) or alanine transaminase (ALT) ≤ 3 x upper limit of normal (ULN) * Serum aspartate transaminase (AST) or alanine transaminase (ALT) ≤ 3 is permissible if due to disease. * Bilirubin ≤3 x ULN (unless bilirubin rise is due to Gilbert's syndrome or of non-hepatic origin) * Estimated Creatinine Clearance ≥30 ml/min (Cockcroft-Gault based on actual weight) (See Appendix A) * Eastern Cooperative Oncology Group (ECOG) performance status of ≤ 3 (Appendix A) * Female subjects who are of non-reproductive potential (i.e., post-menopausal by history - no menses for ≥1 …