HPV Vaccination in HIV Infected and HIV Uninfected Adolescents in Eswatini

Inclusion Criteria: For people living with HIV receiving two-dose regimen: * Females 9-26 years and males 9-14 years, * Documented HIV infection, * Aware of HIV+ status, * Currently receiving antiretroviral treatment (ART) for HIV infection for at least six months, * Living in Eswatini, * For individuals 18+ years: able to provide informed consent, * For individuals 15-17 years: able to provide informed assent, * For individuals 9-14 years of age: able to provide informed assent AND accompanied by an adult caregiver who is able to give informed consent, * Intending to remain in the vicinity of the study sites for the study period For reference group of HIV-uninfected women receiving three-dose regimen: * Females 15-26 years, * Documented negative HIV test at baseline * Living in Eswatini, * Able to provide informed assent (15-17 years) or informed consent (18-26 years) * Intending to remain in the vicinity of the study sites for the study period Exclusion Criteria: For all participants: * Diagnosis of other immunosuppressive diseases or receipt of immunosuppressive medications, * Diagnosis of other acute or chronic illness, * Receipt of other vaccinations within 2-3 weeks before or after study vaccination, * Receipt of blood-derived products within 6 months before or during the study, * Previous receipt of an HPV vaccine, * Currently pregnant, * Known allergies to a vaccine component