This phase II trial studies the effects of combination therapy with bevacizumab, erlotinib, and atezolizumab in treating patients with hereditary leiomyomatosis and kidney cancer that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced). Bevacizumab is in a class of medications called antiangiogenic agents. They work by stopping the formation of blood vessels that bring oxygen and nutrients to tumors. This may slow the growth and spread of tumors. Erlotinib is in a class of medications called kinase inhibitors. It works by blocking the action of a protein called EGFR that signals cancer cells to multiply. This helps slow or stop the spread of cancer cells. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Combination therapy with bevacizumab, erlotinib, and atezolizumab may stabilize or shrink advanced hereditary leiomyomatosis and kidney cancer.
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Incidence of adverse events
Timeframe: Up to 28 days after treatment
Objective response rate
Timeframe: Up to 2 years from study enrollment
Disease control rate
Timeframe: Up to 2 years from study enrollment
Progression-free survival time (PFS)
Timeframe: Time from study treatment initiation until disease progression or death, assessed up to 2 years from study enrollment
Overall survival (OS)
Timeframe: From study treatment initiation until death from any cause, assessed up to 2 years from study enrollment
Duration of response (DOR)
Timeframe: Length of time without disease progression or recurrence, up to 2 years from study enrollment
Response to treatment
Timeframe: Assessed up to 2 years from study enrollment