This study will compare the current standard-of-care pain treatment regimen options that are available to patients who undergo gender-affirming surgery. The purpose of this research is to determine if any of these options are more (versus less) effective than the others to manage surgery related pain, after surgery.
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Changes in peri-operative pain location and intensity over time, as measured by anatomic pain maps
Timeframe: Any time pain is experienced, starting on the morning of post-operative Day 1 to End of Study at the final post-operative visit (average of 30 days after surgery)
Changes in opioid consumption per 24 hours, measured by total inpatient and total outpatient
Timeframe: Per 24 hours, starting on post-operative Day 1 to End of Study at the final post-operative visit (average of 30 days after surgery)
Change in the opioid side effect of urinary retention, as indicated by time to spontaneous voiding
Timeframe: Post-operative Day 1 to Discharge (average of 7 days after surgery)
Change in the opioid side effect of urinary retention, as measured by a Urinary Bother Symptom Score Questionnaire
Timeframe: Pre-operative visit, Discharge (average of 7 days after surgery), and End of Study/final post-operative visit (average of 30 days after surgery)
Change in the opioid side effect of decreased GI motility and ileus, as indicated by number of post-operative days until commencement of regular passage of flatus
Timeframe: Post-operative Day 1 to Discharge (average of 7 days after surgery)
Change in the opioid side effect of nausea, as indicated by number of post-operative days to toleration of liquid diet and regular diet, as well as reported experience of nausea
Timeframe: Post-operative Day 1 to Discharge (average of 7 days after surgery)
Post-operative length of inpatient stay
Timeframe: Post-operative Day 1 to Discharge (average of 7 days after surgery)
Global satisfaction with respect to pain and physical comfort, as measured by a Quality of Recovery 15-Item Inventory
Timeframe: Daily, starting on the morning of post-operative Day 1 to End of Study at the final post-operative visit (average of 30 days after surgery)
Frequency of treatment complications
Timeframe: End of study (average of 30 days after surgery)