WithdrawnNot Applicable

Pulmonary Assessment in Thoracic Insufficiency Syndrome Patients

Stopped: Discontinued relationship with vendor. Currently investigating alternatives.

United States0Started 2026-01

Plain-language summary

Thoracic insufficiency syndrome (TIS) is a complex condition that involves chest wall deformities that can affect normal breathing and lung growth. In most cases, children with TIS are also born with spine disorders such as scoliosis. The inability of the thorax to support normal respiration or lung growth can cause respiratory distress and even mortality. Investigators aim to validate MRI imaging sequences to use as an assessment tool for pulmonary function.

Who can participate

Age range6 Years – 18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Males or females 6 to 18 years old diagnosed with thoracic insufficiency syndrome who are undergoing surgery Exclusion Criteria: * patients not diagnosed with thoracic insufficiency syndrome

What they're measuring

Analyze volume of lungs at end-inspiration and end-expiration

Timeframe: up to 2 years

Xenon-129 MRI Ventilation Maps

Timeframe: up to 2 years

Trial details

NCT IDNCT04977830

SponsorPatrick Cahill, MD

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-08-30

View on ClinicalTrials.gov More Thoracic Insufficiency Syndrome trials