CompletedNot Applicable

Adjunctive Game Intervention for Anhedonia in MDD Patients

China50 participantsStarted 2021-09-09

Plain-language summary

This is a pilot study using game intervention as an adjuvant treatment, to evaluate the effect of the video game on anhedonia and associated functional change of brain in patients with depression. Participants will be randomized to Experimental group receiving a 8-week treatment of antidepressant drugs and game intervention, or Control group receiving a 8-week treatment of antidepressant drugs. Magnetic resonance imaging scanning and assessment of clinical characteristics and cognitive function were conducted before and after the intervention.

Who can participate

Age range18 Years – 60 Years

SexALL

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Inclusion Criteria: * a diagnosis of Major Depressive Disorder according to DSM IV or V and validated via Mini International Neuropsychiatric Interview (M.I.N.I.) * right handedness * capability of understanding and finishing self-rating scales * capability of providing informed consent Exclusion Criteria: * any other major psychiatric disorders following DSM-5 diagnostic criteria * neurological diseases * a history of drug abuse * suicidal risk * pregnancy * any contraindication for brain MRI scan.

What they're measuring

Snaith-Hamilton-Pleasure Scale (SHAPES)

Timeframe: From baseline to 8 weeks

Temporal Experience of Pleasure Scale (TEPS)

Timeframe: From baseline to 8 weeks

Hamilton Depression Rating scale (HAMD)

Timeframe: From baseline to 8 weeks

Trial details

NCT IDNCT04977232

SponsorCentral South University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-12-31

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