Brolucizumab for CNV Associated With Pathologic Myopia (NCT04976244) | Clinical Trial Compass
UnknownNot Applicable
Brolucizumab for CNV Associated With Pathologic Myopia
Ukraine50 participantsStarted 2021-04-01
Plain-language summary
The purpose of this study is to determine the effectiveness of antiangiogenic therapy to choroidal neovascularization secondary to pathologic myopia.
Who can participate
Age range18 Years – 80 Years
SexALL
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Inclusion Criteria:
* Able to read (or, if unable to read due to visual impairment, be read to verbatim by the person administering the informed consent form or a family member) and understand the informed consent form and willing to sign the informed consent form.
* Signed informed consent form.
* Men and women ≥ 18 years of age.
* Willing, committed, and able to return for all clinic visits and complete all study-related procedures.
* Myopia of greater than or equal to -6 D OR axial length of greater than (if the spherical myopic equivalent is \<6.0 diopters, then the patient should have myopic changes in the macula: lacquer cracks, focal chorioretinal atrophy, posterior staphyloma) or equal to 26.5 mm.
* Active subfoveal or juxtafoveal (within 1 to 199 μm of the center of the fovea) CNV secondary to pathologic myopia as defined by leakage on FA.
* Transparent optical media and possibility to mydriasis.
* Best corrected visual acuity at least 20/200 Equivalent of Snellen (ETDRS).
Exclusion Criteria:
* Ocular media of insufficient quality to obtain fundus and OCT images in the study eye
* Recurrent mCNV in the study eye
* History or presence of CNV with an origin other than pathologic myopia in the study eye
* Ocular inflammation or external ocular inflammation in the study eye
* Concurrent disease in the study eye that would compromise BCVA or require medical or surgical intervention during the study period
* Any ocular disorder in the study eye that, in the opinion of t…
What they're measuring
1
Mean Change in Best Corrected Visual Acuity (BCVA) as Measured by ETDRS Chart
Timeframe: Baseline-Month 12
Trial details
NCT IDNCT04976244
SponsorThe Filatov Institute of Eye Diseases and Tissue Therapy