Adjunct Targeted Temperature Management in Acute Severe Carbon Monoxide Poisoning (NCT04975867) | Clinical Trial Compass
CompletedNot Applicable
Adjunct Targeted Temperature Management in Acute Severe Carbon Monoxide Poisoning
South Korea37 participantsStarted 2021-10-25
Plain-language summary
This randomized trial will investigate important neurocognitive clinical outcomes of patients with acute severe carbon monoxide poisoning (ASCOP) randomized to receive either therapeutic hypothermia or normothermia combined with hyperbaric oxygen therapy (HBO).
Who can participate
Age range
19 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* ≥ 19 years.
* Patients who received HBO within 24 hours for acute CO poisoning.
* Patients who meet the definition of ASCOP (Patients incapable verbal obey after HBO).
* Signed informed consent prior to study entry.
Exclusion Criteria:
* Cardiac arrest before HBO
* Previous neurocognitive disorders
* Life-threatening underlying disease (ex: advanced cancer)
* Evidence of co-ingestion of sedative or hypnotics confirmed by intravenous flumazenil administration or history taking at the emergency department
* Absolute contraindication for TH (active severe bleeding and profound shock not controlled by vasoactive drugs)
* No admission
* The significant co-ingested drug levels, which are alter the consciousness, is confirmed from the drug analysis lab
* Pregnancy
* Burns
* More than moderate burn or Inhalation burn
* Burns complicated by other trauma
* Electrical burn
* Burns in high risk patients (Patients with chronic underlying diseases (i.e DM, ESRD, liver cirrhosis, etc) which may cause delays or aggravate the wound healing)
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.