SIGNATURE Study : DCB (Legflow) vs POBA in Fempop Arteries

Inclusion criteria * Patient is ≥18 years * Patient has Rutherford Classification 2,3 or4. * Patient has provided written informed consent and is willing to comply with study follow-up requirements. * De novo stenotic or occlusive lesion(s) or non-stented restenotic or occlusive lesion(s) occurring \>90 days after prior plain old balloon (POBA) angioplasty or \>180 days after prior DCB treatment. * Target lesion is located between the ostium of the SFA and the end of the P1 segment of the popliteal artery * Target vessel diameter ≥ 4 mm and ≤ 7 mm * Target lesion must be stenotic or occlusive lesion ≤ 150mm in length (one long lesion or tandem lesions) by investigator's visual estimate. \[Note: tandem lesions must have a total length of ≤ 150 mm by visual estimate and be separated by ≤ 30 mm.\] * Target lesion must have angiographic evidence of ≥ 70 % stenosis by investigator's visual estimation * Successful, uncomplicated crossing of the target lesion occurs when the tip of the guidewire is distal to the target lesion without the occurrence of flow-limiting dissection of perforation and is judged by visual inspection to be within the true lumen. Subintimal dissection techniques may be used if re-entry occurs above-the-knee (ATK) and without the use of re-entry devices. * Target lesion is located at least 30mm from any stent if target vessel was previously stented. * A patent inflow artery free from significant stenosis ((≥50% stenosis) as confirmed by angiography. * At leas…