2000HIV Trained Innate Immunity in HIV Elite Controllers

All participants: * All participants must be ≥18 years of age. * Due to distorting effects on immune parameters and immune responses, participation is either not possible or must be delayed in case of the following: * active hepatitis B/C or signs of acute infections * active or recent malignant condition (i.e. \<12 months ago treated) * active systemic auto-immune or auto-inflammatory conditions (such as rheumatoid arthritis, inflammatory bowel disease). * use of immunosuppressive medication * pregnant HIV elite controllers: HIV elite controllers in the 2000HIV that have an available first-degree relative. Definition of HIV elite controller is the same as in the 2000HIV, see definition on page 7 of the protocol and in the group description. ART-suppressed people living with HIV: As a control group, ART-suppressed people living with HIV in the 2000HIV that have an available first-degree relative will be included. ART-suppressed people living with HIV need to apply to the following criteria to participate in the 2000HIV: ≥18 years, on cART ≥6 months with an HIV-RNA load \<200 copies/mL. For this 2000HIV-trained study, additional criteria for ART-suppressed people living with HIV are: * Never applied to controller definition. * At least one documented HIV RNA load \>100.000 copies/mL * No documentation of recent HIV acquisition combined with ART initiation in less than 6 months. Eligible ART-suppressed people living with HIV will be matched by sex and age (m…