Post-Intensive Care Syndrome - Pediatrics (PICS-p): Longitudinal Cohort Study (NCT04967365) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Post-Intensive Care Syndrome - Pediatrics (PICS-p): Longitudinal Cohort Study
United States755 participantsStarted 2021-07-27
Plain-language summary
Pediatric Intensive Care Unit (PICU) survival has increased substantially over the past three decades. Currently, an understanding of PICU morbidity and recovery among PICU survivors and their families is limited. Post-intensive care syndrome (PICS) consists of new or worsening impairments in physical, cognitive, or mental health status that arise and may persist after critical illness. The characteristics of PICS in children (PICS-p) are unknown. The objective of this study is to learn about pediatric recovery from critical illness to guide future intervention research to optimize child and family health.
Who can participate
Age range1 Month – 16 Years
SexALL
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Inclusion criteria
✓. Current admission is the child's first PICU (including pediatric subspecialty ICU) admission
✓. Patient age ≥4 weeks and ≥44 weeks corrected gestational age and \<16 years (has not yet reached 16th birthday) on PICU admission
✓. At least one parent/legal guardian (≥18 years of age or considered emancipated) living with the potential subject
✓. PICU LOS of 3 days (covering at least 3 nights from midnight to 7am) in which the patient received intensive care therapies for organ dysfunction (for example, invasive mechanical ventilation, vasopressors/inotropes, acute renal replacement therapy, or other extracorporeal therapies).
✓. Anticipated patient discharge to home (directly or indirectly after a stay in another facility)
Exclusion criteria
✕. Patient history of neonatal intensive care unit hospitalization
✕. Life expectancy not anticipated to be more than one year (e.g., active do not resuscitate \[DNR\] plan or actively managed by the palliative care team for end-of-life symptom management)