The aim of this study is to determine if Nociception Level (NOL)-guided Remifentanil analgesia, combined with Entropy-guided Propofol anesthesia, has a significant beneficial effect on the incidence of intraoperative hypotension episodes and/or on vasopressor requirements, during long-lasting major surgeries for high risk patients. The investigator will also investigate the effects of guided anesthesia on postoperative Myocardial Injury in Non-cardiac Surgery (MINS) and Postoperative cognitive dysfunction (POCD), amongst other frequent postoperative complications, in this population.
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Occurrence of intraoperative hypotension
Timeframe: during surgery
Total Vasopressor Dose
Timeframe: during surgery
Number of interventions to cure intraoperative hypotension
Timeframe: during surgery
Total Time under hypotension thresholds
Timeframe: during surgery