Advanced Mesenchymal Enhanced Cell THerapY for SepTic Patients

Inclusion criteria

• ✓. Adult patients age 18 years and older
• ✓. Receipt of appropriate antibiotics for the suspected/confirmed bacterial sepsis as the main diagnosis according to the opinion of the treating staff physician.
• ✓. Hypotension documented within 48 hours prior to enrolment that requires the institution and ongoing use of vasopressor agents (phenylephrine, norepinephrine, vasopressin, epinephrine, or dopamine \>5 mcg/kg/min) for at least 3 hours within 24 hours prior to infusion, despite adequate fluid resuscitation in the opinion of the qualified investigator.
• ✓. At least 1 other new organ dysfunction defined by the following:
• ✓. Renal: Acute kidney injury with creatinine ≥ 150 µmol/L, or ≥ 1.5x the upper limit of normal or the known baseline creatinine, or \< 0.5 ml/kg/hr urine output for 6 hours despite adequate fluid resuscitation or requirement for new renal replacement therapy (patients on chronic hemodialysis or peritoneal dialysis must meet one of the other organ dysfunction criteria)
• ✓. Respiratory: Need for invasive mechanical ventilation or a P/F ratio \< 250
• ✓. Hematological: Platelets \< 100 x10\^9/L, or a drop of 50 x10\^9/L in the 3 days prior to enrollment
• ✓. Metabolic Acidosis: Arterial pH \< 7.30 in association with base deficit \> 5 mmol/L OR a lactate \>/= to 3.0 mmol/L