The purpose of the study is to investigate if there are common biopsychosocial vulnerability factors for developing and maintaining fatigue, regardless of the diagnosis. The investigators also believe that subgroups differ in terms of these factors. Participating patients with ME/CFS, burnout syndrome and post-covid fatigue complete a web form at inclusion and after 1, 2, 4, 6, 12, 18 and 24 months. There is no upper limit for the number of participants in the web survey. 150 participants are asked to submit blood samples at a local laboratory in connection with the questionnaires for analysis of inflammatory markers and one urine sample for analysis of nutritional markers. Two control groups are included, 150 patients with rheumatoid arthritis and 50 healthy individuals. The longitudinal design makes it possible to investigate how inflammatory markers, nutritional status, symptom burden, health related quality of life co-vary over time and how work ability and sick leave is affected.
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Change in fatigue (Multidimensional Fatigue Inventory)
Timeframe: baseline and 1, 2, 4, 6, 12, 18 and 24 months
Change in symptom burden
Timeframe: baseline and 1, 2, 4, 6, 12, 18 and 24 months
Change in Generalized sickness behavior (Sickness questionnaire)
Timeframe: baseline and 1, 2, 4, 6, 12, 18 and 24 months
Change in health related quality of life (World health organization disability assessment scale)
Timeframe: baseline and 1, 2, 4, 6, 12, 18 and 24 months
Change in Inflammatory markers
Timeframe: baseline and 1, 2, 4, 6, 12, 18 and 24 months
Dietary intake
Timeframe: 6 months
Nutritional status
Timeframe: 6 months
Change in self-reported work ability
Timeframe: baseline and 1, 2, 4, 6, 12, 18 and 24 months