MyoMobile Study: App-based Activity Coaching in Patients with Heart Failure and Preserved Ejection Fraction

Inclusion Criteria: * Age ≥ 45 years * Diagnosis of HFpEF * LVEF \> 40% by any imaging modality at screening within 4 months prior to study entry * Current HF symptoms as defined as presence of dyspnea according to New York Heart Association \[NYHA\] functional class I to III at screening visit * Stable HF treatment for at least 4 weeks prior to screening * At least one of the following 3 criteria need to be fulfilled: (1) NT-proBNP ≥ 300pg/ml; (2) Hospitalization for HF within the past 12 months; (3) Symptom(s) of HF requiring treatment with diuretic(s) for at least 30 days prior to screening visit * Wearing time of the physical activity monitor for at least 4 days during the baseline assessment * Average daily step count during baseline assessment ≥ 1,000 steps per day and \< 10,000 steps per day Exclusion Criteria: * Acute decompensated HF requiring augmented therapy with diuretic agents, vasodilator agents, and/or inotropic drugs * Participants who are non-ambulatory managed or use mobility assistive devices such as motorized devices or wheelchairs * Acute coronary syndrome (including myocardial infarction), cardiac surgery, other major cardiovascular surgery or urgent percutaneous coronary intervention (PCI) within 3 months prior to visit 1 or an elective PCI within 30 days after study enrolment * Probable alternative diagnoses that in the opinion of the investigator account for the patient's HF symptoms (i.e., dyspnea, fatigue) * Participants with physical a…