Gemcitabine, Nab-paclitaxel, Durvalumab, and Oleclumab Before Surgery for the Treatment of in Resectable/Borderline Resectable Primary Pancreatic Cancer

Inclusion Criteria: * Capable of giving written informed consent which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in this protocol. Written informed consent includes any locally required authorization (e.g., Health Insurance Portability and Accountability Act in the US, European Union \[EU\] Data Privacy Directive in the EU) obtained from the patient/legal representative prior to performing any protocol-related procedures, including screening evaluations * Age \>= 18 years at time of study entry * Has histologically or cytologically confirmed resectable or borderline resectable pancreatic adenocarcinoma per MD Anderson criteria (borderline patients based upon reconstructable superior mesenteric vein/portal vein \[SMV/PV\] involvement or reconstructable hepatic artery involvement are allowed) * Has received no prior anti-cancer therapy for pancreatic adenocarcinoma * Has an Eastern Cooperative Oncology Group (ECOG) performance status of 0-1 * Hemoglobin \>= 9.0 g/dL * Absolute neutrophil count 1.5 x (\>= 1500 per mm\^3) * Platelet count \>=100 x 10\^9/L (\>= 100,000 per mm\^3) * Serum bilirubin =\< 1.5 x institutional upper limit of normal (ULN). This will not apply to patients with confirmed Gilbert's syndrome (persistent or recurrent hyperbilirubinemia that is predominantly unconjugated in the absence of hemolysis or hepatic pathology), who will be allowed only in consultation with their physician. Subjects requi…