Predicting Fluid Responsiveness During Shock in Newborns and Infants by End-expiratory Occlusion … (NCT04932590) | Clinical Trial Compass
CompletedNot Applicable
Predicting Fluid Responsiveness During Shock in Newborns and Infants by End-expiratory Occlusion Test
France10 participantsStarted 2021-12-24
Plain-language summary
To date, the end-expiratory occlusion test in infants or children has never been evaluated as a marker of preload dependence. It therefore appears clinically relevant to evaluate this new indicator to predict fluid responsiveness in all infants hospitalized in pediatric and neonatal intensive care.
The main objective of this study is to determine whether the hemodynamic effects of a 15-second end-expiratory occlusion were able to predict fluid responsiveness in the mechanically ventilated infant or newborn in pediatric intensive care.
Who can participate
Age range0 Years – 2 Years
SexALL
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Inclusion Criteria:
* Newborn and infant \<2 years.
* Born at or near term (\> 36 weeks of amenorrhea).
* Hospitalized in pediatric and neonatal intensive care.
* Requiring the use of invasive mechanical ventilation.
* In a state of shock defined by a cardio-circulatory dysfunction associating arterial hypotension, an alteration in organ perfusion, one or more organ dysfunctions or vasopressor's requirement. Clinical signs retained: heart rate ≥ 90th percentile associated with at least one sign of peripheral hypoperfusion represented by a a capillary refill time ≥ 3sec, or the presence of mottling or coldness of the extremities or urine output ≤ 0.5ml / kg / h or disturbance of consciousness.
* The practitioner in charge of the patient has decided to perform volume expansion.
* Non-opposition expressed by the holders of parental authority.
Exclusion Criteria:
* Any serious and urgent clinical hemodynamic situation, the management of which would be delayed by inclusion in the protocol.
* Patient with unoperated congenital heart disease.
* Patient in spontaneous or non-invasive ventilation or with spontaneous ventilatory cycles in invasive ventilation.
* Patient in prolonged cardiac arrest (\> 5min) or refractory.
* Patient under venous-arterial extracorporeal membrane oxygenation.
* Refusal of the holders of parental authority to exploit the collected data.